Here some comments from an authority are known in dermatology, Dr. Norman Orentreich, in his article: biology for hair growth from the scalp, plastic surgery clinics-vol. 9, no. 2, therapy from 1982: locale [-] progesterone, a natural and meaningful 5aR inhibitor in in vitro, in the system hgh mpb of microsomes from human skin, a rich source of 5aR tested and proven in the hair follicles of the human scalp. Progesterone in alcoholic solution, applied to the skin of the pubis of normal men, if it has caused a drop in average 75. 2 percent of 5aR after 24 hours after treatment. Also, although less DHT, be more steroids (DHP; 5A-Pregnane-3, 20dione). DHH is competing with the remaining for DHT cytosol nuclear protein for further reducing the amount of DHT in interaction with genetic material. Progesterone works in the production of DHT on the spot in the competition to reduce the active page of 5aR and should have been present at the active site at all times, because the reversible kinetics. Differences in treatment lead to the resumption of production of DHT from testosterone. Because the progesterone inhibits the production of DHT and DHH partially inhibits the binding of DHT residue, androgenetic alopecia only local and too little progesterone can weaken. Because over 70% of topical application in skin progesterone is metabolized weak, Nonandrogenic can be used the by-products in women at a rate of 1 ml of a solution with 2% offer, while higher doses of irregularities of the menstrual cycle. Also a good place would be to it what he said Sawaya and Shapiro in his article about alopecia: unapproved treatments or clinical indications in dermatology 2000; 18: 177-186: indications, more progesterone ovary disorders and contraception. Off-label uses specified different effectiveness as an agent for topical treatment of AGA in a concentration of 2%. We found that progesterone topical very useful in the treatment of AGA. However, it seems that progesterone topical may help a bit, but there is to write something at home. .